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Neil Ayres

Title: Assistant Professor
Office: 902 Crosley Tower
Tel: 513-556-9280
Email: neil.ayres@uc.edu
Web: http://homepages.uc.edu/~ayresni/

Neil Ayres received his Ph. D. in chemistry from The University of Warwick in 2003 where he worked with Prof. David Haddleton.  After a post-doc with Charles McCormick at The University of Southern Mississippi he worked with William Brittain at The University of Akron studying stimuli-responsive polymer brushes.  From there he spent two years as a post-doc at The University of Utah with Prof. David Grainger before becoming an assistant professor at The University of Cincinnati in 2008.

His current research interests include using controlled radical polymerization methods for new materials synthesis and polymer therapeutics and synthesizing new peptidomimetic oligomers with self-assembly properties.

Education

  • Ph. D., University of Warwick, U. K., 2002 (Chemistry).
  • B. Sc. , University of Warwick, U. K., 1999 (Chemistry).

Research Information

Research Interests

Synthetic polymer chemistry, with an emphasis on controlled/"living" radical polymerization. Polymer bioconjugates and biomimetics. Polymerizations from surfaces. Stimuli responsive polymers.

Research Support

  • (PI), Neil Ayres, Synthesis of Heparin mimicking polymers containing N-alkyl urea peptoids and their evaluation in anticoagulation assays, National Science Foundation. (DMR-1206150), 275000. 09/01/2012 to 08/30/2015. Status: Active.
  • (PI), Ayres, Neil, N-Alkyl Urea Peptoid Oligomers as a New Type of Self-Assembling, Highly Versatile Soft Materials for Applications Involving Organogelators, American Chemical Society - National Chapter. (PRF 51850-DN17), $100,000.00. 01/01/2012 to 08/31/2014. Status: Active.
  • (PI), Ayres, Neil, Synthesis of Heparin Mimicking Polymers Containing N-alkyl Urea Peptoids and their Evaluation in Anticoagulation Assays, National Science Foundation. (DMR-1206150), $183,000.00. 09/01/2012 to 08/31/2015. Status: Active.

Publications

Peer Reviewed Publications

  • Ayres N. (2011) Atom Transfer Radical Polymerization: A Robust and Versatile Route for Polymer Synthesis Polymer Reviews 51(2) 138-162
  • Chen X., Ayres N. (2011) Synthesis of Low Grafting Density Molecular Brush from a Poly(N-alkyl urea peptoid) Backbone Journal of Polymer Science, Part A: Polymer Chemistry 49(14) 3030-3037
  • Chen X., Ding K., Ayres N. (2011) Investigation into fiber formation in N-alkyl urea peptoid oligomers and the synthesis of a water-soluble PEG/N-alkyl urea peptoid oligomer conjugate Polymer Chemistry 2 2635
  • Chen X., Ayres N. (2010) Synthesis of Novel Polymer/Urea Peptoid Conjugates using RAFT polymerizationMacromolecules 43(3) 1341-1348
  • Ayres N. (2010) Polymer Brushes: Applications in Biomaterials and Nanotechnology Polymer Chemistry 1 769-777 
  • Ayres N.; Holt D. J.; Jones C. F.; Corum, L.E.; Grainger D. W. "Polymer brushes containing sulfonated sugar repeat units: Synthesis, characterization, and in vitro testing of blood coagulation activation". Journal of Polymer Science, Part A: Polymer Chemistry (2008), 46, 7713--7724.
  • Ayres, N.; Cyrus, C. D.; Brittain, W. J. "Stimuli-Responsive Surfaces using Polyampholyte Polymer Brushes Prepared via Atom Transfer Radical Polymerization". Langmuir (2007), 23, 3744-3749.
  • Ayres, N.; Boyes, S. G.; Brittain, W. J. "Stimuli-Responsive Polyelectrolyte Polymer Brushes Prepared via Atom Transfer Radical Polymerization". Langmuir (2007), 23, 182-189.
  • Ezell, R. G.; Gorman, I.; Lokitz, B.; Ayres, N.; McCormick, C. L. "Amino Acid-Based pH-Responsive Ampholytic Terpolymers of N-Acryloyl-Valine, acrylamide, and (3-Acrylamidopropyl)trimethylammonium Chloride: Synthesis, Characterization and Solution Properties". Journal of Polymer Science, Part A: Polymer Chemistry (2006), 44, 3125-3139.
  • Treat, N. D.; Ayres, N.; Boyes, S. G.; Brittain, W. J. "A Facile Route to Poly(Acrylic Acid) Brushes using Atom Transfer Radical Polymerization". Macromolecules (2006), 39, 26-29.
  • Vasilieva, Y. A.; Scales, C. W.; Thomas, D. B.; Ezell, R. G.; Lowe, A. B.; Ayres, N.; McCormick, C. L. "Controlled/'Living' Polymerization of Methacrylamide Directly in Aqueous Media via the RAFT process". Journal of Polymer Science, Part A: Polymer Chemistry (2005), 43, 3141-3152.
  • Thomas, D. B.; Convertine, A. J.; Myrick, L. J.; Scales, C. W.; Smith, A. E.; Lowe, A. B.; Vasilieva, Y. A.; Ayres, N.; McCormick, C. L. "Kinetics and Molecular Weight Control of the Polymerization of Acrylamide via RAFT". Macromolecules (2004), 37, 8941-8950.
  • Convertine, A. J.; Ayres, N.; Scales, C. W.; Lowe, A. B.; McCormick, C. L. "Facile, Controlled, Room-Temperature RAFT Polymerization of N-Isopropylacrylamide". Biomacromolecules (2004), 5, 1177-1180.
  • Ayres N., Haddleton D. M., Pascual S., Shooter A. J., Pears D. A. "Synthesis of Hydrophilic Polar Supports Based on Poly(dimethylacrylamide) via Copper Mediated Living Radical Polymerization from a Cross-Linked Poly(styrene) surface". Macromolecules (2002), 35, 3849--3855.
  • Angot S., Ayres N, Bon S. A. F., Haddleton D. M. "Living Radical Polymerization immobilized on Wang Resin: Synthesis and Harvest of Narrow Polydispersity Poly(Methacrylates)". Macromolecules (2001), 34, 768--774.
  • (2013) Xiaoping Chen, Pengzhan Fei, Kevin A Cavicchi WenwenYang, and Neil Ayres The poor solubility of ureidopyrimidone can be used to form gels of low molecular weight N-alkyl urea oligomers in organic solvents Manuscript accepted to Colloid and Polymer Science 
  • Yongshun Huang, Leeanne Taylor, Xiaoping Chen, and Neil Ayres (2013) Synthesis of a Polyurea from a Glucose or Mannose Containing N-alkyl Urea Peptoid Oligomer Journal of Polymer Science, Part A: Polymer Chemistry 51(24) 5230-5238
  • Taylor L., Chen X., Ayres N. (2014) Synthesis of a glycosaminoglycan polymer mimetic using an N-alkyl-N,N-linked urea oligomer containing glucose pendant groups Polymer International 63 127-135 

Editorial

  • Supramolecular and Dynamic Covalent Polymers

Encyclopedia Article

  • McCormick, C. L.; Lowe, A. B.; Ayres, N. Polymers, Water-Soluble. In Kirk-Othmer Encyclopedia of Chemical Technology, 5th ed., 2006; Vol. 20, pp 435, 504.
  • McCormick, C. L.; Lowe, A. B.; Ayres, N. Water Soluble Polymers. In Encyclopedia of Polymer Science & Technology, 3rd Edition; John Wiley & Sons: New York, 2004; Vol. 12, pp 452, 521.

Presentations & Lectures

Invited Presentations

  • Neil Ayres (11/02/2011). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates University of Southern Mississippi, Hattiesburg, MS.
  • Neil Ayres (10/09/2011). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates Colorado School of Mines, Golden, CO.
  • Neil Ayres (09/09/2011). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates Case Western Reserve University, Cleveland, OH.
  • Neil Ayres (2010). Water Soluble Polymers: Synthesis, Characterization, and Applications Proctor & Gamble, Cincinnati, OH.
  • Neil Ayres (2010). Polymer-urea peptoid conjugates: A versatile materials chemistry platform University of Cincinnati, Chemical and Materials Engineering Department.
  • Neil Ayres (2010). Controlled/"living" radical polymerization as a tool for the synthesis of of polymer brushes and polymer conjugates Hillsdale College, Hillsdale, MI.
  • Neil Ayres (2009). Polymer Brushes using atom transfer radical polymerization Wright State University, Dayton, OH.
  • Neil Ayres (12/06/2011). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates University of New Hampshire, Durham, New Hampshire.
  • Neil Ayres (01-2012). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates Rutgers University - Newark, Newark, New Jersey.
  • Neil Ayres (01-2012). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates SUNY Stony Brook, Stony Brook, NY.
  • Neil Ayres (02-2012). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates Clarkson University, Potsdam, New York.
  • Neil Ayres (05-2012). Polymers incorporating N-alkyl urea peptoids: Self-assembled aggregates, step-growth polymers and polymer conjugates Oak Ridge National Laboratory – Center for Nanophase Materials Sciences, Oak Ridge, Tennessee.
  • Neil Ayres (11-2012). Polymer synthesis using N-alkyl urea peptoid oligomers Murray State University, Murray, Kentuck.
  • Neil Ayres (04-2012). Self-assembly of N-alkyl urea peptoid polymers and oligomers 243rd American Chemical Society National Meeting, San Diego, CA.
  • Neil Ayres (04-2012). Polymer synthesis using N-alkyl urea peptoid oligomers 243rd American Chemical Society National Meeting, San Diego, California.
  • Neil Ayres (07-2012). Polymer synthesis incorporating N-alkyl urea peptoid oligomers Warwick 2012: MacroGroup UK International Conference on Polymer Synthesis, University of Warwick, United Kingdom.
  • Neil Ayres (2013). Synthesis of synthetic biomaterials incorporating N-alkyl-N,N-linked urea oligoemrs 246th American Chemical Society, Indianapolis, IN.

Paper Presentations

  • Neil Ayres (2010). Polymer Urea-Peptoid Conjugates: A versatile materials platform. 240th American Chemical Society National Meeting, Boston, MA.
  • Neil Ayres (2010). Polymer Urea-Peptoid Conjugates: A versatile materials platform. 41st Central Regional Meeting of the American Chemical Society, Dayton, OH.
  • (2006). Synthesis of Polyelectrolyte Polymer Brushes using Atom Transfer Radical Polymerization. Macro Group U.K. International Symposium on Polymer Synthesis, Coventry, U.K..
  • (2004). Towards the Controlled Polymerization of Amino-Acid Containing Monomers. 228th American Chemical Society National Meeting, Philadelphia, U.S.A..
  • (2004). Structural control of water-soluble homopolymers and block copolymers via RAFT polymerization. 228th American Chemical Society National Meeting, Philadelphia, U.S.A..
  • (2002). Polymerization of vinyl monomers from an insoluble PS-DVB matrix. Macro Group U.K. International Symposium on Polymer Synthesis, Coventry, U. K..

Poster Presentations

  • Neil Ayres (08-2011). The use of N-alkyl urea peptoids in macromolecular synthesis Gordon Research Conference: Polymers, Mount Holyoke College, MA.
  • Neil Ayres (07-2011). The use of N-alkyl urea peptoids in macromolecular synthesis 242nd American Chemical Society National Meeting, Denver, CO.
  • Neil Ayres (2009). Synthesis of Polymer Brushes from a Transferable Surface Coating 238th American Chemical Society National Meeting, Washington, D. C..
  • Neil Ayres (2009). Synthesis of Polymer Brushes from a Transferable Surface Coating Gordon Research Conference: Biomaterials: Biocompatibility/Tissue Engineering, Holderness School, NH.
  • (2005). Towards Recyclable Catalysts for Atom Transfer Radical Polymerization 230th American Chemical Society National Meeting, Washington, D.C., U.S.A..
  • (2005). Towards Recyclable Catalysts for Atom Transfer Radical Gordon Research Conference: Polymers (East), Mount Hollyoke College, Massachusetts, U.S.A..
  • (2001). Synthesis of a novel polmer support via a transition metal mediated living radical polymerization 221st American Chemical Society National Meeting, San Diego, USA.
  • (2000). Polymerization of hydrophilic monomers onto solid surfaces Royal Society of Chemistry Annual Conference, Manchester, U.K..

Honors & Awards

  • Darwin T. Turner Scholars Program (UC Ethnic Programs & Services) “Breakfast of Champions” faculty recognition.

Experience & Service

Work Experience

  • 10-2006 to 08-2008, Post-Doctoral Research Associate, University of Utah, Salt Lake City, UT.
  • 12-2004 to 10-2006, Post-Doctoral Research Associate, University of Akron, Akron, OH.
  • 01-2003 to 12-2004, Post-Doctoral Research Associate, University of Southern Mississippi, Hattiesburg, MS.

Events Organized

  • Symposium. Zimmer International Scholar Week (04-2012 to 04-2012) , University of Cincinnati.

Service

  • Committee Member, Department of Chemistry NMR faculty liaison committee, 2013
  • Committee Member, Department of Chemistry RPT guidelines review committee, 2010
  • Committee Member, Department of Chemistry Headship search committee, 2013 to 2013
  • Judge, College of Engineering and Applied Science REU site, 2013
  • Other, Preparing Future Faculty Program 2013

Courses Taught

  • 15-CHEM-201 ORG CHEM LEC & REC
    Level: Undergraduate
    Term: 12W
  • 15-CHEM-622 PREPERXNS OF POLYMR
    Level: Both
    Term: 12S
  • Organic Chemistry and Recitation
    Organic Chemistry and Recitation
    Level: Undergraduate
    Term: 13SS
  • Polymers and Soft Materials
    Polymers and Soft Materials
    Level: Undergraduate
    Term: 13SS
  • Molecular Interactions
    Molecular Interactions
    Level: Graduate
    Term: 13FS