Biological Sciences

Biological Sciences

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Edwin R Griff

Title: Associate Professor
Undergraduate Director
Office: 721A Rieveschl Hall
Tel: 513-556-9739
Email: edwin.griff@uc.edu

Education

  • Ph.D., Purdue University, West Lafayette, IN, 1979 (Biology).
  • BA, Brandeis University, Waltham, MA, 1970 (Biology).

Research Information

Research Interests

The overall goal of my research is to understand the physiological mechanisms that produce sensation. My current research investigates the sense of smell, olfaction. In olfaction, chemical odorants stimulate olfactory receptor neurons in the nose, which in turn stimulate neurons in the olfactory bulb of the brain called mitral cells. These cells respond to stimuli by producing nerve impulses (action potentials), and the primary strategy used in my lab is to record these electrical responses using electrophysiological techniques. Thus, a student joining my lab would learn to stimulate and record the responses of neurons in the olfactory system.


Important physiological questions include: how are the various cells are connected to each other in neural circuits; what is the source and temporal pattern of spontaneous activity in each neuron; how does each cell generate its response; do these responses interact in time and space, and finally, how do these responses code olfactory information? Recent anatomical and molecular data suggests that the olfactory bulb is organized into units called glomeruli where about 1000 olfactory receptor neurons, each expressing the same receptor protein, converge onto about 25 mitral cells. To what aspect of an odorant do these cells respond? Do they all respond in the same way to stimulation? Do they all exhibit the same pattern of background activity in the absence of stimulation? How do these cells interact with mitral cells in adjacent glomeruli? These are some of the specific questions that we hope to answer in the next few years.
My previous work involved the visual system, examining functional interactions between rod photoreceptors and the retinal pigment epithelium. We showed that absorption of light by rods produced a sequence of membrane potential changes mediated by a light-evoked decrease in extracellular potassium. A rapid apical membrane hyperpolarization was followed by a delayed basal membrane depolarization, and these epithelial membrane changes produced slow components of the electroretinogram, the c-wave and fast-oscillation trough. Subsequent studies have linked these electrical changes to ion transport across the epithelium, and visual manifestations of cystic fibrosis.

Research Support

  • (PI), Edwin R. Griff, The source of spontaneous neural activity in the olfactory bulb, University Research Council. (URC), 3,450. 01-2011 to 12-2011. Status: Active.
  • (PI), Griff, Edwin, Spontaneous Activity of Mitral Cells in the Intact Rat, National Institute on Deafness and Other Communication Disor. (R15-DC04548-01A2NCE), $147,617.00. 07/01/2002 to 06/30/2005. Status: Closed.
  • (PI), Edwin Griff, Marcus Johnson, Students’ Engagement and Evaluations of Instructional Effectiveness by Instructor Status in Anatomy and Physiology Labs, IDEA Impact Grant. 11,672. 05-2017 to 09-2018. Status: Denied.

Publications

Peer Reviewed Publications

  • Griff, E.R. and Matter, S.F. 2013. Evaluation of an adaptive online learning system.  British Journal of Educational Technology 44:170-176.
  • Edwin R. Griff , Nancy K. Kleene, and Steven J. Kleene.  2012. A Selective PMCA Inhibitor Does Not Prolong the Electroolfactogram in Mouse. PLoS ONE 7(5): e37148. doi:10.1371/journal.pone.003714.
  • Stakic, J., Suchanek, J.M., Ziegler, G.P., and E. Griff. 2011. The source of spontaneous activity in the main olfactory bulb of the rat. PLoS ONE 6(8): 23990.doe:10.1371/journal.pone.0023990.
  • Griff, E. R, Matter, S. and Nica, R. 2010. Physiological evidence for two classes of mitral cells in the rat olfactory bulb.  Brain Research 1958: 81-88.
  • Griff, E. R. and Kane, T. 2010.  A housefly sensory-motor integration laboratory.  Advances in Physiology Education 34:106-110.
  • Griff, E. R., & Matter, S.F. (2008). Early identification of at-risk students using a personal response system. British Journal of Educational Technology, 39, 1124-1130. [Link]
  • Griff, E., Mafhouz, M., Perrut, A., & M. Chaput (2008). Comparison of identified mitral and tufted cells in freely breathing rats: I. conduction velocity and spontaneous activity. Chemical Senses, 33, 779-792. [Link]
  • Griff, E., Mafhouz, M., & M. Chaput (2008). Comparison of identified mitral and tufted cells in freely breathing rats: II. odor-evoked responses. Chemical Senses, 33, 793-802. [Link]
  • Mast, T.G., & Griff, E. R. (2007). The effects of analgesic supplements on neural activity in the main olfactory bulb of the mouse. Comparative Medicine, 57, 167-174. [Link]
  • Griff, E. R. (2006). How neurons work: An analogy and demonstration using a sparkler and a frying pan. American Biology Teacher, 68, 412-417. [Link]
  • Mast, T.G., & Griff, E. R. (2005). In vivo preparation and identification of mital cells in the main olfactory bulb of the mouse. Brain Research Protocols, 15, 105-113. [Link]
  • Phillips, S., Griff, E. R. (2002). Impulse conduction of olfactory receptor neuron axons. Microscopy research and technique, 58(3), 161, 167. [Link]
  • Griff, E. R., Greer, C. A., Margolis, F., Ennis, M., Shipley, M. T. (2000). Ultrastructural characteristics and conduction velocity of olfactory receptor neuron axons in the olfactory marker protein-null mouse. Brain research, 866(1-2), 227, 236. [Link]
  • El-Etri, M. M., Ennis, M., Griff, E. R., Shipley, M. T. (1999). Evidence for cholinergic regulation of basal norepinephrine release in the rat olfactory bulb. Neuroscience, 93(2), 611, 617. [Link]
  • Jiang, M. R., Griff, E. R., Ennis, M., Zimmer, L. A., Shipley, M. T. (1996). Activation of locus coeruleus enhances the responses of olfactory bulb mitral cells to weak olfactory nerve input. Journal of Neuroscience, 16(19), 6319, 6329. [Link]
  • Haugh-Scheidt, L. M., Griff, E. R., Linsenmeier, R. A. (1995). Light-Evoked Oxygen Responses in the Isolated Toad Retina. Experimental eye research, 61(1), 73, 81. [Link]
  • Haugh-Scheidt, L. M., Linsenmeier, R. A., Griff, E. R. (1995). Oxygen-Consumption in the Isolated Toad Retina. Experimental eye research, 61(1), 63, 72. [Link]
  • Griff, E. R. (1991). Potassium-Evoked Responses from the Retinal-Pigment Epithelium of the Toad Bufo-Marinus. Experimental eye research, 53(2), 219, 228. [Link]
  • Griff, E. R. (1990). Metabolic-Inhibitors Reversibly Alter the Basal Membrane-Potential of the Gecko Retinal-Pigment Epithelium. Experimental eye research, 50(1), 99, 107. [Link]
  • Griff, E. R. (1990). Response Properties of the Toad Retinal-Pigment Epithelium. Investigative ophthalmology & visual science, 31(11), 2353, 2360. [Link]
  • Gallemore, R. P., Griff, E. R., Steinberg, R. H. (1988). Evidence in Support of a Photoreceptoral Origin for the Light-Peak Substance. Investigative ophthalmology & visual science, 29(4), 566, 571. [Link]
  • Scharschmidt, B. F., Griff, E. R., Steinberg, R. H. (1988). Effect of Taurine on the Isolated Retinal-Pigment Epithelium of the Frog - Electrophysiologic Evidence for Stimulation of an Apical, Electrogenic Na+-K+ Pump. Journal of Membrane Biology, 106(1), 71, 81. [Link]
  • Griff, E. R., Shirao, Y., Steinberg, R. H. (1985). Ba-2+ Unmasks K+ Modulation of the Na+-K+ Pump in the Frog Retinal-Pigment Epithelium. Journal of General Physiology, 86(6), 853, 876. [Link]
  • Griff, E. R., Steinberg, R. H. (1984). Changes in Apical [K+] Produce Delayed Basal Membrane Responses of the Retinal-Pigment Epithelium in the Gecko. Journal of General Physiology, 83(2), 193, 211. [Link]
  • Griff, E. R., Pinto, L. H. (1984). Observations on Rod Coupling in the Isolated Retina of Bufo-Marinus. Vision research, 24(2), 149, 157. [Link]
  • Steinberg, R. H., Linsenmeier, R. A., Griff, E. R. (1983). 3 Light-Evoked Responses of the Retinal-Pigment Epithelium. Vision research, 23(11), 1315, 1323. [Link]
  • Griff, E. R., Steinberg, R. H. (1982). Origin of the Light Peak - Invitro Study of Gekko-Gekko. Journal of Physiology-London, 331(OCT), 637, 652. [Link]
  • Griff, E. R., Pinto, L. H. (1981). Interactions among Rods in the Isolated Retina of Bufo-Marinus. Journal of Physiology-London, 314(MAY), 237, 254. [Link]
  • Favela, L.H., Coey, C.A., Griff, E.R., Richardson. M.J. 2016.  Fractal analysis reveals subclasses of neurons and suggests an explanation of their spontaneous activity. Neuroscience Letters 626:54–58.[Link]
  • Griff, E.R. 2016. Changing Undergraduate Human Anatomy and Physiology Labs: Perspectives from a Large-Enrollment Course. Advances in Physiology Education 40:388–392.[Link]
  • Steady-state centrifugal input via the lateral olfactory tract modulates spontaneous activity in the rat main olfactory bulb. Ford NC and Griff ERNeuroscience 348: 165–179, 2017.[Link]

Published Abstract

  • Favela, L.H., Coey, C.A., Griff, E.R. and M.J. Richardson. 2014. Fractal analysis of spontaneous activity in single neurons.  Society for Neuroscience.  Washington, D.C.
  • Neil C. Ford, Edwin R. Griff. 2012. Blocking the lateral olfactory tract in vivo alters spontaneous activity in the main olfactory bulb of the rat.  Association for Chemorecptive Sciences (AChemS)
  • Suleiman, J. H., Griff, E. R. (1993). Recovery from Detachment in the Toad Retina [Abstract]. Investigative ophthalmology & visual science, 34(4), 957, 957.
  • Haugh, L. M., Linsenmeier, R. A., Griff, E. R. (1992). Oxygen-Consumption of the Isolated Toad Retina during Dark and Light Adaptation [Abstract]. Investigative ophthalmology & visual science, 33(4), 838, 838.
  • Haugh, L. M., Griff, E. R., Linsenmeier, R. A. (1991). Light-Evoked Oxygen Responses in the Isolated Toad Retina [Abstract]. Investigative ophthalmology & visual science, 32(4), 671, 671.
  • Jiang, M., Griff, E.R., Zimmer, L.A., Ennis, M., & Shipley, M.T. (1993). Locus coeruleus increases perithreshold sensory-evoked excitation of mitral cells. [Abstract]. Association for Chemoreception Sciences (AchemS).
  • Griff, E.R., Margolis, F.L., Ennis, M, & Shipley, M.Y. (1998). Conduction velocity of olfactory receptor neurons in the OMP-null mutant mouse [Abstract]. Association for Chemoreception Sciences (AchemS).
  • Jiang, M., Griff, E.R., Zimmer, L.A., Ennis, M., & Shipley, M.T. (1993). LC activation increases perithreshold sensory excitation of olfactory bulb mitral cells [Abstract]. Society for Neuroscience.
  • Griff, E.R. & Bonasso, C.L (1990). A light peak in the toad, Bufo marinus [Abstract]. Invest Ophthalmol. Vis. Sci., Suppl., 31, 391.
  • Griff, E.R. & Law, N.G. (1989). Light-evoked responses from the RPE of Bufo marinus. [Abstract]. Invest. Ophthalmol. Vis. Sci., Suppl., 30, 44.
  • Griff, E.R. (1988). Metabolic dependence of RPE membrane potentials [Abstract]. Invest. Ophthalmol. Vis. Sci., Suppl., 39, 93.
  • Steinberg, R.H., Gallemore, R.P. & Griff, E.R. (1987). Origin of the light peak: contribution from the neural retina [Abstract]. Invest. Ophthalmol. Vis. Sci., Suppl., 28, 402.
  • "Blocking the lateral olfactory tract alters spontaneous activity of neurons in the main olfactory bulb of the rat in vivo" Ford NC and Griff ER. Poster presentation at the 2012 meeting of the Ohio Miami Valley Chapter of the Society for Neuroscience. Oxford, OH

Textbooks Authored

  • Zao, P., Stabler, T., Smith, L., Lokuta, A., and E. Griff. 2012. PhysioEx 9.0: Laboratory simulations in Physiology. Pearson Education Inc., San Francisco, CA.

Presentations & Lectures

Invited Presentations

  • Edwin R. Griff (04-2010). Lab simulation programs for Anatomy and Physiology- Updates and enhancements to the Physio-Ex Neurophysiology exercise Innovations 2010, Cincinnati, OH.

Lectures

  • (08/31/2013). Research opportunities. Research Careers course, Rieveschl 615.
  • (01/11/2013). Research opportunities. Research Careers course, Rieveschl 615.
  • Research opportunities. Research Careers course.
  • Research opportunities. Research Careers course.
  • Research opportunities. Research Careers course.
  • Research opportunities. Research Careers course.
  • Research opportunities. Research Careers course.
  • Research opportunities. Research Careers course.

Experience & Service

Post Graduate training and Education

  • 1979 to 1985, Retinal physiologist, University of California Medical School, San Francisco, CA.

Service

  • Member, Department of Biological Sciences Teaching Effectiveness committee, 01/03/2010 to 12/15/2010
  • Member, College of Arts and Sciences Curriculum Committee, 01/03/2010 to Present
  • Member, AAUP Associates Council, 01/03/2010 to 09/01/2012
  • Committee Member, Undergraduate Affairs, 09-2011 to Present
  • Committee Chair, Undergraduate Research and Honors, 09-2011 to Present
  • Committee Member, Spring Event Planning , 01-2012 to Present
  • Director, Director of Undergraduate Research, 01-2011 to 01-2017
  • Member, UC task force on convervion to semesters for Arts and Sciences, 01/01/2008 to 05/01/2008
  • Neuroscience Steering Committee, 2012 to Present
  • Committee Member, Faculty Assessor for the 2011 Undergraduate Research Poster Session, 06/03/2011 to 06/03/2011
  • Committee Member, Undergraduate Research Committee, 11/01/2011 to 06/01/2012
  • Committee Chair, Undergraduate Studies, 08-2016 to Present
  • Member, Undergraduate Council, 08-2016 to Present
  • Member, Human Anatomy & Physiology Society (HAPS) Curriculum, 05-2016 to Present
  • Member, Pre-Health Advising Center Pre-Health Advisory Board, 03-2016 to Present

Courses Taught

  • 15-BIOL-201 ANAT & PHYS I
    Level: Undergraduate
    Term: 09A
    Comments: I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, proctoring lab exams, attending lab meetings, and organizing staff meetings.
  • 15-BIOL-201 ANAT & PHYS I
    Level: Undergraduate
    Term: 09A
    Comments: I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, proctoring lab exams, attending lab meetings, and organizing staff meetings.
  • 15-BIOL-201 ANAT & PHYS I
    Level: Undergraduate
    Term: 10W
    Comments: I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, and organizing staff meetings.
  • 15-BIOL-201 ANAT & PHYS I
    Term: 10A
    Comments: I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, proctoring lab exams, attending lab meetings, and organizing staff meetings.
  • 15-BIOL-201 ANAT & PHYS I
    Level: Undergraduate
    Term: 10A
    Comments: I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, proctoring lab exams, attending lab meetings, and organizing staff meetings.
  • 15-BIOL-540 NEUROBIOLOGY
    Level: Both
    Term: 11A
    Comments: I last taught this course in Winter 2008; it therefore required extensive revision. Also, the number of students increased from 25 to 40 requiring a different approach to presentations. [Link]
  • 15-BIOL-202 ANAT & PHYS II
    Level: Undergraduate
    Term: 12W
    Comments: I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, proctoring lab exams, attending lab meetings, and organizing staff meetings. [Link]
  • -BIOL-2001C ANAT PHYS I
    Level: Undergraduate
    Term: 12FS
    Comments: I am one of the course directors. I give all the lectures. I help administer lab sections including signing students into lab sections, responding to emails about lab sections, supervising staff and teaching assistants, assisting in ordering equipment, proctoring lab exams, attending lab meetings, and organizing staff meetings.
  • -BIOL-4095 UNDERGRAD RESEARCH
    Level: Undergraduate
    Term: 12FS
    Comments: For section 013, I train and supervise students doing electrophysiology of the olfactory bulb. For section 034, I coordinate research for students working in laboratories outside of the Biology Department
  • Anatomy & Physiology I
    Anatomy & Physiology I
    Level: Undergraduate
    Term: 14FS
    Comments: Teaching lab was a new preparation for me. I shadowed 1 section and taught 3
  • Neurobiology
    Neurobiology
    Level: Undergraduate
    Term: 14FS