McMicken College of Arts & SciencesMcMicken College of Arts & SciencesUniversity of Cincinnati

McMicken College of Arts & Sciences

Department of Chemistry

Department of Chemistry

Chemistry

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James Mack

Title: Associate Professor and Assistant Head
Office: 502 Crosley Tower
Tel: 513-556-9249
Email: james.mack@uc.edu
Web: http://www.mackchem.org

James Mack is an AssociateProfessor of Chemistry. After completing his Bachlor’s degree at Middlebury College in 1995 he went to graduate school at the University of New Hampshire where he conducted his doctoral research under the supervision of Glen P. Miller working in the area of fullerenes. After earning his doctoral degree in 2000, he was a postdoctoral fellow with Lawrence T. Scott developing a bench top synthesis of fullerenes and nanotubes. Since joining the faculty at the University of Cincinnati in 2003, Professor Mack has been interested in the development of environmentally benign organic reactions and the synthesis of novel organic materials.

Education

  • bachelor of arts, Middlebury College, Middlebury Vermont, 1995 (Chemistry).
  • Doctor of Philosophy, University New Hampshire, Durham, New Hampshire, 2000 (Chemistry).

Research Information

Research Support

  • (PI), James Mack, CAREER: Utilization of Mechanochemistry for solvent waste prevention, National Science Foundation. (CHE-0548150), 550000. 2006 to 2011. Status: Active.
  • (PI), James Mack, “Shaken not stirred: Utilization of mechanochemistry for solvent prevention”, University Research Council. 5000. 2005. Status: Active.
  • Green Chemistry Gordon Conference Travel Grant. 2004.
  • (PI), James Mack, Developing a better understanding of organic reactions under solvent-free ball milling conditions, National Science Foundation. (041064767), 367835. 10/01/2011 to 09/30/2014. Status: Active.
  • (Co-PI), Michael Gonalez, James Mack, Developing and Assessing Sustainable Pharmaceutical Reactions in a Continuous Flow Environment , American Chemical Society. 100000. 2011 to 2011. Status: Denied.
  • (Co-PI), James Mack, Joanna Mitro, Margaret Hanson, Ilya Vilinsky, Kenneth Petren, Jodi Shann, Stephan Pelikan, Using retention strategies and academic support to build a first generation pipeline to Science and Math, NSF. (1154468), 600000. 2011 to 2016. Status: Denied.
  • (PI), Mack, James, Utilization of Mechanochemistry for Solvent Waste Reduction, National Science Foundation. (CHE-0548150), $564,310.00. 04/01/2006 to 03/31/2011. Status: Closed.
  • (PI), Iyer, Suri; Mack, James, CAREER: Tailored Glycoconjugates for the Precise Detection of Toxins and Pathogens, National Science Foundation. (CHE-0845005), $575,000.00. 08/01/2009 to 07/31/2014. Status: Active.
  • (PI), Mack, James, Developing a Better Understanding of Organic Reactions Under Solvent-Free Ball Milling Conditions, National Science Foundation. (CHE-1058627), $367,835.00. 10/01/2011 to 09/30/2014. Status: Active.

Publications

Peer Reviewed Publications

  • Mack, J.; Fulmer, D.; Stofel, S.; Santos, N. "The first solvent-free method for the reduction of esters". Green Chem (2007), 1041-1043.
  • Mack, J.; Vogel, P.; Jones, D.; Kaval, N.; Sutton, A. "The development of corannulene-based blue emitters". Org. Biomol. Chem. (2007), 5, 2448-2452.
  • "Rate Enhancement of the Morita-Baylis-Hillman Reaction through Mechanochemistry ". Green Chem. (2007), 9, 328-330.
  • Scanlon, L. G., ;Balbuena, P. B., ;Zhang, Y., ;Sandi, G., ;Back, C. K., ;Feld, W. A., ;Mack, J., ;Rottmayer, M. A., ;Riepenhoff, J. L. "Investigation of Corannulene for Molecular Hydrogen Storage via Computational Chemistry and Experimentation". J. Chem. Phys. B (2006), 110, 7688-7694.
  • Denifl, S., ;Sonnweber, B., ;Mack, J., ;Scott, L. T., ;Scheier, P., ;Becker, K., ;Maerk, T. D. "Appearance energies of singly, doubly, and triply charged coronene and corannulene ions produced by electron impact". Int. J. Mass. Spec. (2006), 249/250, 353-358.
  • Petrukhina, M. A., ;Andreini, K. W., ;Mack, J., ;Scott, L. T. "X-ray Quality Geometries of Geodesic Polyarenes from Theoretical Calculations: What Levels of Theory Are Reliable?". J. Org. Chem. (2005), 70, 5713-5716.
  • Lovas, F. J., ;McMahon, R. J., ;Grabow, J.-U., ;Schnell, M., ;Mack, J., ;Scott, L. T., ;Kuczkowski, R. L. "Interstellar Chemistry: A Strategy for Detecting Polycyclic Aromatic Hydrocarbons in Space". J. Am. Chem. Soc. (2005), 127, 4345-4349.
  • Hauke, F., ;Atalick, S., ;Guldi, D. M., ;Mack, J., ;Scott, L. T., ;Hirsch, A. "Molecular satellite dishes: attaching parabolic and planar arenes to heterofullerenes ". Chem. Commun. (2004), 766-767.
  • Miller, G. P.; Briggs, J.; Mack, J.; Lord, P. A.; Olmstead, M. M.; Balch, A. L. "Fullerene-Acene Chemistry: Single-Crystal X-ray Structures for a [60]Fullerene-Pentacene Monoadduct and a cis-Bis[60]fullerene Adduct of 6,13 Diphenylpentacene ". Organic Letters (2003), 5, 4199-4202.
  • M.A. Petrukhina, K.W. Andreini, J. Mack, L.T. Scott. "Transition-Metal Complexes of an Open Geodesic Polyarene". Angew. Chem. Int. Ed. (2003), 42, 3375.
  • 1.     "Solvent-free Sonogashira coupling reaction via high speed ball milling" Fulmer, D. A., Shearouse, W. C., Medonza, S. T. and Mack, J., Green Chem.  2009, 11, 1821-1825
  • Waddell, D. C.; Thiel, I.; Clark, T. D.; Marcum, S. T.; Mack, J. Green. Chem. 2010, 12, 209-211.
  •  "A two-step ball milling method synthesizes and purifies α,β-unsaturated esters" Shearouse, W. C., Korte, C. M. and Mack, J., Green. Chem. 13, 598-601
  • Investigating the Formation of Dialkyl Carbonates Using High Speed Ball Milling, Waddell, D. C.; Thiel, I.; Bunger, A.; Nkata, D.; Maloney, A.; Clark, T.; Smith, B.; Mack, J. Green. Chem. 2011, 13, 3156.
  • Mechanochemistry: Opportunities for New and Cleaner Synthesis, S. L. James, C. J. Adams, C. Bolm, D. Braga, P. Collier, T. Friscic, F. Grepioni, K. D. M. Harris, G. Hyett, W. Jones, et. al, Chemical Society Reviews, 2012, 41, 413-447.
  • Conducting Moisture Sensitive Reactions Under Mechanochemical Conditions, D. C. Waddell, T. D. Clark, J. Mack, Tetrahedron Letters, 2012, 53, 4510-4513.
  • Diastereoselective Liquid Assisted Grinding: 'Cracking' Functional Resins to Advance Chromatography-free Synthesis, W. C. Shearouse, J. Mack, Green Chem., 2012, 14, 2771-2775.
  • Scratching the Catalytic Surface of Mechanochemistry: A Multi-component CuAAC Reaction Using a Copper Reaction Vial, T. L. Cook, J. A. Walker, Jr., J. Mack, Green Chem., 2013, 15, 617-619.
  • Effect of Acid and Alcohol Network Forces within Functionalized Multiwall Carbon Nanotubes Bundles on Adsorption of Copper (II) Species, S. Rosenzweig, G. A. Sorial, E. Sahle-Demessie, J. Mack, Chemosphere, 2013, 90, 395-402.
  • A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-Aryl Ketones via Mechanochemistry, W. C. Shearouse, M. Z. Shumba, J. Mack, Applied Sciences, 2014, 4, 171-179.
  • Comparison of Shaking versus Baking: Further Understanding the Energetics of a Mechanochemical Reaction, K. S. McKissic, J. T. Caruso, R. G. Blair, J. Mack, Green Chemistry, 2014, 16, 1628-1632.
  • Freedom: A Copper-Free, Oxidant-Free and Solvent-Free Palladium Catalysed Homocoupling Reaction, L. Chen, B. E. Lemma, J. S. Rich, J. Mack, Green Chemistry, 2014, 16, 1101-1103.

Book Chapter

  • Experimental and Calculated Properties of Fullerene and Nanotube Fragments, D. R. Jones, P. Bachawala, J. Mack, Chapt. 5, in Fragments of Fullerenes and Carbon Nanotubes, Eds. M. A. Petrukhina and L. T. Scott, John Wiley & Sons, Inc., Hoboken, NJ, 2012, 135-156.
  • Hemispherical Geodesic Polyarenes: Attractive Templates for the Chemical Synthesis of Uniform-Diameter Armchair Nanotubes, A. P. Belanger, K. A. Mirica, J. Mack, L. T. Scott, Chapt. 9, in Fragments of Fullerenes and Carbon Nanotubes, Eds. M. A. Petrukhina and L. T. Scott, John Wiley & Sons, Inc., Hoboken, NJ, 2012, 135-156.
  • Solvent-Free Synthesis, J. Mack, S. Muthukrishnan, Chapt. 11, in Green Techniques for Organic Synthesis and Medicinal Chemistry, 1st Ed., Eds. W. Zhang and B. W. Cue, Jr., John Wiley & Sons, Inc., Hoboken, NJ, 2012, xxxx-xxxx.

Presentations & Lectures

Invited Presentations

  • (09-2006). The development of Greener Syntheses through Mechanochemistry St. John's University.
  • (09-2006). The design and synthesis of corannulene-based materials Barnard College.
  • (04-2006). The use of computational chemistry to solve real world problems University of Cincinnati, Physics Department.
  • (04-2006). The development of Greener Syntheses through Mechanochemistry Northern Kentucky University.
  • (04-2006). The development of Greener Syntheses through Mechanochemistry ACS-Trisection Meeting.
  • (03-2006). The development of Greener Syntheses through Mechanochemistry College of Mount Saint Joseph.
  • (03-2006). The development of Greener Syntheses through Mechanochemistry Western Kentucky University.
  • (01-2006). The design and synthesis of corannulene-based materials Shawnee State University.
  • (12-2005). The development of Greener Syntheses through Mechanochemistry Indiana University-Purdue University, Fort Wayne.
  • (12-2005). The development of Greener Syntheses through Mechanochemistry Geneva College.
  • (12-2005). The development of Greener Syntheses through Mechanochemistry Murray State University.
  • (02/25/2005). The design and synthesis of corannulene-based nanomaterials Wright State University.
  • (02/16/2005). The design and synthesis of corannulene-based nanomaterials Olivet College.
  • James Mack (02-2007). The development of Greener Syntheses through Mechanochemistry” Millikin Univerisity.
  • James Mack (10-2007). It is Easy Being Green MIddlebury College.
  • James Mack (11-2007). The development of Greener Syntheses through Mechanochemistry Tennessee Technical Univerisity.
  • James Mack (02-2008). “The development of Greener Syntheses through Mechanochemistry” Hampton University.
  • James Mack (04-2008). “The development of Greener Syntheses through Mechanochemistry” Howard University.
  • James Mack (09-2008). Understanding organic reactions through mechanochemistry Miami (OH) University.
  • James Mack (10-2009). Coupling reaction via high speed ball milling” University of Maryland-Eastern Shore.
  • James Mack (07-2010). Shake it up: chemistry through high speed ball milling” Univerisity of Callifornia-Davis.
  • Daniel Waddell (10-2010). Making dialkyl carbonates under high speed ball milling conditions Ohio Northern University.
  • James Mack (12/08/2011). Shake it up: Chemistyr via High Speed Ball Milling American Chemical Society meeting, Xavier University .
  • James Mack (05/09/2012). Shaken not Stirred: Chemistry through High Speed Ball Milling University of Central Florida.
  • James Mack (10/04/2012). “Shaken not Stirred”: Chemistry through High Speed Ball Milling Xavier University of Louisiana.
  • James Mack (11/02/2012). “Shaken not Stirred”: Chemistry through High Speed Ball Milling Indiana University-Purdue University, Fort Wayne.
  • James Mack (06/19/2012). Bizzarro World: Understanding the rules that govern mechanochemical reactions 34th Reaction Mechanisms Conference, Columbia, Missouri.
  • James Mack (10/04/2013). Bringing Corannulene into the Light Shawnee State University Chem Club.
  • J. Mack*, W. C. Shearouse, D. C. Waddell, T. L. Cook (04/07/2013). (63) Reducing the Need for Petroleum Based Solvents through Mechanochemistry in the Symposium on Green Chemistry Fostered Advances for Chemicals and Fuel Production 245th American Chemical Society National Meeting, New Orleans, LA.
  • T. L. Cook, W. C. Shearouse, D. C. Waddell, J. A. Walker, K. M. Leahy, J. Mack* (09/08/2013). (66) Developing Greener Synthetic Pathways through Mechanochemistry 246th American Chemical Society National Meeting, Indianapolis, IN.
  • James Mack (10/03/2014). "Shaken not Stirred": Chemistry through High Speed Ball Milling Georgia Institute of Technology.
  • James Mack (10/08/2014). "Shaken not Stirred": Chemistry through High Speed Ball Milling Oberlin College.
  • James Mack (10/16/2014). "Shaken not Stirred": Chemistry through High Speed Ball Milling Ball State University.
  • James Mack (11/18/2014). "Shaken not Stirred": Chemistry through High Speed Ball Milling SPEX Sample Preparation.

Paper Presentations

  • (03-2006). The development of Corannulene based materials. NSF-EPSRC Organic Materials Workshop, London, England.
  • M. Shumba, D. Fulmer, J. Mack (07-2005). the development of Greener synthesis through mechanochemistry. 2. Physical Organic Chemistry Gordon Research Conference, Holderness, NH.
  • M. Shumba, J. Mack (07-2004). the development of Greener synthesis through mechanochemistry. 3. Green Chemistry Gordon Research Conference, Providence, RI.
  • (06-2004).. Organic Dynamics Workshop, Greenwich WI.
  • M. Shumba, J. Mack (10-2004). The utility of a water-soluble azo compound and sodium hypophosphite in solventless free radical reaction. Oesper Symposium, Cincinnati, OH.
  • M. Shumba, J. Mack (10-2006). Rate enhancement of the Baylis-Hillman reaction via mechanochemistry. Oesper Symposium, Cincinnati, OH.
  • J. Riepenhoff and J. Mack (10-2004). The study and synthesis of Corannulene-based Carcerands. Oesper Symposium, Cincinnati, OH.
  • J. Riepenhoff and J. Mack (2006). The study and synthesis of Corannulene-based Carcerands. National ACS meeting.
  • D. Fulmer and J. Mack (10-2004). Green Chemistry: The Viability Phase-Transfer and Oxidation Reactions in the Solid State. Oesper Symposium, Cincinnati, OH.
  • D. Fulmer and J. Mack (07-2005). Green Chemistry: The Viability Phase-Transfer and Oxidation Reactions in the Solid State. ACS green Chemistry Summer School.
  • D. Fulmer and J. Mack (06-2006). The development of Solvent-free reductions via mechanochemistry. National Green Chemistry Conference.
  • A. Hurst and J. Mack (10-2004). Studying the Host-Guest interactions of tethered corannulene units with electron deficient metals. Oesper Symposium, Cincinnati, OH.
  • A. Hurst and J. Mack (04-2005). Studying the Host-Guest interactions of tethered corannulene units with electron deficient metals. NOBCChE.
  • S. Figueira and J. Mack (10-2004). Establishing HSVM as a versatile, Convenient, Environmentally Safer Method for Conducting Reactions. Oesper Symposium, Cincinnati, OH.
  • S. Figueira, J. Mack (2004). Establishing HSVM as a versatile, Convenient, Environmentally Safer Method for Conducting Reactions. Regional Mcnair Conference, Columbus, OH.
  • S. Figueira, J. Mack (2004). Establishing HSVM as a versatile, Convenient, Environmentally Safer Method for Conducting Reactions. National Mcnair Conference, Madison, WI.
  • R. Vermillion and J. Mack (10-2004). Solid State reduction of Carbonyl Groups via HSVM. Oesper Symposium, Cincinnati, OH.
  • Daniel Waddell (06-2010). Making dialkyl carbonates under high speed ball milling conditions. Central Regional Meeting of the American Chemical Society.
  • Daniel Waddell (02-2010). Environmentally Benign Chemistry Through High Speed Ball Milling. Chemistry Graduate Student Association Speaker of the Year Symposium, University of Cincinnati.
  • Daniel Waddell (06/22/2011). Organic synthesis using high speed ball milling. Green Chemistry and Engineering Conference, Washington D.C..
  • Teresa Cook and James Mack (08/19/2012). (58) Exploring Metal Catalyzed Reactions Under Solvent-Free High Speed Ball Milling (HSBM) Conditions. ACS National Meeting, Philadelphia, PA.
  • T. L. Cook*, J. Mack (04/07/2013). (64) Using High Speed Ball Milling (HSBM) to Design Greener Organic Syntheses in the Symposium on New Reactions and Methodology. 245th American Chemical Society National Meeting, Indianapolis, IN.
  • K. S. McKissic*, A. D. Gudmundsdottir, J. Mack (09/08/2013). Photoswitchable Corannulene Derivatives. 246th American Chemical Society National Meeting, Indianapolis, IN.
  • L. Chen*, B. E. Lemma, J. S. Rich, M. Regan, M. Radulea, J. Mack (08/14/2014). Environmentally Benign Method for Homocoupling Reaction by Using a Recyclable Catalyst via High Speed Ball Milling. 248th American Chemical Society National Meeting, San Francisco, CA.
  • K. M. Leahy*, P. Carr, J. Mack (08/10/2014). Recover and Reuse: Polymer-Supported Reagents Under Ball Milling Conditions. 248th American Chemical Society National Meeting, San Francisco, CA.
  • H. M. Hopgood*, A. Fuhrman, R. Ransohoff, B. Walden, J. Mack (08/10/2014). Substitution Without Solution: The Effects of a Solventless System on the Reactivity of Sterically Hindered Reagents. 248th American Chemical Society National Meeting, San Francisco, CA.

Poster Presentations

  • Daniel Waddel1. Daniel Waddell, Indre Thiel, Tammara Clark, and S. Tyler Marcum (10-2010). Making dialkyl carbonates under high speed ball millilng conditions Oesper Symposium.
  • Daniel Waddell, Indre Thiel, Tammara Clark, and S. Tyler Marcum (07-2010). Making dialkyl carbonates under high speed ball millilng conditions Green Chemistry Gordon Conference, Davidson NC.
  • Teresa Cook and James Mack (07/01/2012). Exploring Metal Catalyzed Reactions Under Solvent-Free High Speed Ball Milling (HSBM) ACS Division of Organic Chemistry Graduate Research Symposium, Boulder, CO.
  • K. McKissic*, J. Mack (04/07/2013). Simplified Nitrate Reductase Based Nitrate Dection Method by Thin Layer Controlled Potential Coulometry and Griess Reaction in the Symposium Electroanalytical Measurements 245th American Chemical Society National Meeting, New Orleans, LA.
  • J. Caruso*, K. McKissic, J. Mack (09/08/2013). Understanding Energetics Using High Speed Ball Mill (HSBM) 246th American Chemical Society National Meeting, Indianapolis, IN.
  • A. M. Bergmann*, T. L. Cook, J. Mack (09/08/2013). Understanding Aromatic Substitution Under High Speed Ball Milling (HSBM) 246th American Chemical Society National Meeting, Indianapolis, IN.
  • A. A. Burney-Allen*, T. L. Cook, J. Mack (09/08/2013). Schmidt Reaction Under High Speed Ball Milling 246th American Chemical Society National Meeting, Indianapolis, IN.
  • R. Fox*, S. K. Sarkar, J. Mack, A. D. Gudmundsdottir (03/16/2014). Laser Flash Photolysis of Aromatic Compounds in the Solid State and Solution 247th American Chemical Society National Meeting, Dallas, TX.
  • B. Lemma*, L. Chen, J. Mack (03/16/2014). New Method for Carbon-Carbon Bond Formation of Terminal Alkynes in HSBM 247th American Chemical Society National Meeting, Dallas, TX.

Symposium

  • James Mack (06-2008). Mechanochemistry: Past, Present and Future.”. Central regional meeting of the American Chemical society Professional Meeting. Level: Regional.
  • James Mack (08-2008). The development of Corannulene-based materials. American Chemical Society Professional Meeting. Level: National.
  • James Mack (05-2009). Shake it up: chemistry through high speed ball milling”. Central regional meeting of the American Chemical society Professional Meeting. Level: Regional.
  • James Mack (09-2009). Shaken not stirred: chemistry via high speed ball milling”. Symposium on Mechanochemistry and Solvent-Free Synthesis,, Queen's University Belfast. Professional Meeting. Level: International.
  • James Mack (03-2011). Bringing corannulene into the light. American Chemical Society Professional Meeting. Level: National.
  • James Mack (2011). Bizarro world. international Symposium on mechanochemstry, Queen's University of Belfast. Professional Meeting. Level: International.

Experience & Service

Post Graduate training and Education

  • 2000 to 2003, Postdoctoral fellow, Boston College.

Service

  • Committee Member, Diversity Council, 09-2012 to Present
  • Committee Member, Yates Graduate Fellowship Committee, 2005 to Present
  • Program Director, Graduate Program Director of Advising, 2005 to 2013
  • Other, Faculty Advisor to the Chemistry Graduate Student Association (CGSA), 2009 to Present
  • Other, Faculty Advisor to the UC Student Affiliates of the ACS (SAACS), 2008 to Present
  • Committee Chair, Long Range Immplementation Committee, 2005 to Present
  • Committee Member, Reappointment, Promotion and Tenure Committee, 2009 to Present
  • Committee Chair, Organic Divisional Committee, 2013 to Present
  • Committee Member, Graduate Recruitment and Admissions Committee, 2003 to 2013
  • Committee Member, Graduate Admissions Committee, 2004 to 2013
  • Committee Member, A&S Diversity Task Force 09-2012 to Present
  • Committee Member, Departmental Communications Committee, 2013 to Present

Other Experience and Professional Memberships

  • 2007 to Present ,member, American chemical society

Courses Taught

  • 15-CHEM-351 ORGANIC CHEM II
    Level: Undergraduate
    Term: 10S
  • 15-CHEM-351 ORGANIC CHEM II
    Level: Undergraduate
    Term: 11W
  • 15-CHEM-103 FIRST YR CHEMISTRY
    Level: Undergraduate
    Term: 11S
  • 15-CHEM-761 ORG SPECTROSCOPY
    Level: Graduate
    Term: 11A
  • SPECTROSCOPY FUND.
    SPECTROSCOPY FUND.
    Level: Graduate
    Term: 13FS
  • ORGANIC TOPICS
    ORGANIC TOPICS
    Level: Graduate
    Term: 12FS